The field of oncology benefits from several large-scale reference books and a host of monographs dedicated to specific cancers. However, truly excellent practice and review books are, surprisingly, quite scarce. Outside of a scant handful of books and online reference tools that offer clinical response practice and board review in a basic question and answer format, there are no resources that offer a robust, engaging, fully referenced tool for these vital activities in every oncologist's and oncology trainee's work. This print and electronic book seeks to fill that void, offering comprehensive question-and-answer style content that covers the entire specialty of oncology and provides practicing oncologists with a fascinating and immediately applicable compendium of vital information dealing with a well-balanced selection of common and uncommon cancers. At the heart of this book is the editor's and authors' desire to overcome the controversies and barriers to practice that usually emerge following the appearance of new data. In every section, the user is guided toward collaboration in ongoing clinical research - for example, via discussions of well-designed ongoing clinical trials in each specific area. Developed with both the teacher and learner in mind, this book also offers trainees and fellows an excellent opportunity to enhance their preparation for the ABIM oncology fellowship exam as well as for the oncology boards. It will also be an extremely useful tool for oncologists working toward the recertification exam. This comprehensive, beefy book includes hundreds of painstakingly developed multiple-choice and mini-case-based questions covering the principles of medical oncology, malignant hematology, surgical oncology, and radiation oncology. It also contains mini-cases and questions dealing with the biology, diagnosis, classification, staging, and multidisciplinary treatment of cancers at every anatomic site. The very latest topics are included, such as molecular techniques, targeted therapies, and translational cancer research. Concise but detailed answers are referenced to key journals and books, and evidence-based wherever possible. NCCN guidelines are also referenced as appropriate. With its powerful focus on take-home messages from and for actual clinical work, this book will help keep oncologists up to date, bridging the gaps between journal and reference literature, conferences, and their existing knowledge base.

Syed A. Abutalib, MD, is Assistant Director for Stem Cell Transplantation at the Chicago-area branch of Cancer Treatment Centers of America, or CTCA. CTCA is a group of five private treatment centers in the USA focused on patient care in oncology. For several years now, Dr. Abutalib has authored the very popular and well-received "Clinical Conundrums" feature in the oncologist tabloid paper Clinical Oncology (McMahon Publishing), and this is where the idea came to him to enhance and expand his concept from that experience into this book.

Maurie Markman, MD, is Senior Vice President of Clinical Affairs and National Director of Medical Oncology at Cancer Treatment Centers of America (CTCA). A nationally-renowned oncologist, Dr. Markman has more than 20 years of experience in cancer treatment and gynecologic research at some of the country's most recognized facilities. Dr. Markman has served as the Vice President for Clinical Research and Chairman of the Department of Gynecologic Medical Oncology at M.D. Anderson Cancer Center in Houston, Texas. Prior to that, Dr. Markman spent 11 years as Chairman of the Department of Hematology/Oncology and Director of the Taussig Cancer Center at the Cleveland Clinic Foundation. He also spent five years as Vice Chairman of the Department of Medicine at Memorial Sloan-Kettering Cancer Center in New York.

List of Contributors, x

Preface, xxi

Section 1 Malignant Hematology and Hematopoietic Cell Transplantation

Part 1 Acute Lymphoblastic Leukemia in Adults

1 Diagnosis of acute lymphoblastic leukemia, 5
Frederick G. Behm, Agatha Bogard, Syed A. Abutalib, and Sujata S. Gaitonde

2 Prognostic markers and models in acute lymphoblastic leukemia, 18
Dieter Hoelzer

3 Management of B-cell acute lymphoblastic leukemia, 22
Hady Ghanem, Hagop Kantarjian, Nitin Jain, and Elias Jabbour

4 Management of T-cell acute lymphoblastic leukemia, 29
Daniel J. DeAngelo

5 Minimal residual disease in acute lymphoblastic leukemia, 35
Meir Wetzler

6 Hematopoietic cell transplantation in adult acute lymphoblastic leukemia, 40
Netanel A. Horowitz and Jacob M. Rowe

Part 2 Acute Myeloid Leukemia in Adults

7 Prognosis in acute myeloid leukemia: cytogenetics and beyond, 51
Gordana Raca, Madina Sukhanova, and Lucy A. Godley

8 Induction therapy in acute myeloid leukemia, 58
Tapan Kadia and Farhad Ravandi

9 Consolidation therapy in acute myeloid leukemia, 67
Gregory K. Behbehani and Bruno C. Medeiros

10 Management of acute promyelocytic leukemia, 71
Eytan M. Stein and Martin S. Tallman

11 Minimal residual disease in acute myeloid leukemia, 76
Hans Beier Ommen, Line Nederby, Marie Toft-Petersen, Charlotte Guldborg Nyvold, and Peter Hokland

12 Relapsed and refractory acute myeloid leukemia, 82
Stefan H. Faderl

13 Hematopoietic cell transplantation in acute myeloid leukemia, 89
Antonio M. Jimenez and Stefan O. Ciurea

Part 3 Myelodysplastic Syndromes and Related Disorders

14 Pitfalls in the diagnosis of myelodysplastic syndromes, 99
Jay Yang, Gail Bentley, and Charles A. Schiffer

15 Cytogenetics and prognostic models in myelodysplastic syndromes, 106
Uma Borate and Harry P. Erba

16 Management of myelodysplastic syndromes, 113
Vu H. Duong, Alan F. List, and Rami S. Komrokji

17 Management of therapy-related myeloid neoplasms, 120
Jagoda K. Jasielec and Richard A. Larson

18 Hematopoietic cell transplantation in myelodysplastic syndromes, 126
Antonio Di Stasi, Armin Ghobadi, and Partow Kebriaei

19 Acquired aplastic anemia, 131
Valeria Visconte and Ramon V. Tiu

Part 4 Myeloproliferative Neoplasms

20 Diagnostic approach in myeloproliferative neoplasms, 137
Ayalew Tefferi

21 Chronic myeloid leukemia: chronic phase, 142
Jerald P. Radich

22 Blast crisis of chronic myeloid leukemia, 147
Michael J. Mauro

23 Chronic myeloid leukemia and pregnancy, 150
Michael J. Mauro

24 Polycythemia vera, 152
Constantine S. Tam and Srdan Verstovsek

25 Essential thrombocytosis, 156
Paola Guglielmelli and Alessandro M. Vannucchi

26 Primary myelofibrosis, 162
Ayalew Tefferi

27 Eosinophilic myeloproliferative disorders, 167
Jason Gotlib

28 Chronic myelomonocytic leukemia, 176
Mrinal M. Patnaik

29 Hematopoietic cell transplantation in chronic myeloid leukemia, 180
Jerald P. Radich

30 Hematopoietic cell transplantation in primary myelofibrosis, 187
Irum Khan and Damiano Rondelli

Part 5 Chronic Lymphocytic and Other Leukemias

31 Prognostic markers and management of chronic lymphocytic leukemia, 195
Courtney D. DiNardo and Susan O'Brien

32 Hematopoietic cell transplan...