Cancer Stem Cells covers a wide range of topics in
cancer stem cell biology, including the functional characteristics
of cancer stem cells and how they're generated, where they are
localized, the means by which cancer stem cells can be targeted,
and how cancer stem cells can be reprogrammed back to normal tissue
stem cells. Each chapter begins with a brief historical note and
concept summary, followed by a description of the latest basic or
clinical advance associated with the topic.
Cancer Stem Cells builds systematically from
coverage of the basic research stage to an advanced research level,
from clinical relevance to therapeutic potential, and will be a
valuable resource for professionals in the fields of cancer
research and stem cell biology.
Autorentext
Dr. V.K. Rajasekhar, M.Sc., M.Phil., Ph.D., is a Senior Research Scientist at Memorial Sloan-Kettering Cancer Center, New York. His work with patient derived prostate cancer stem cell xenografts, a first study in renewable Biobanking of these clinically relevant cells, has garnered eclectic post-publication reviews. Dr. Rajasekhar has received competitive research awards from the Alexander von Humboldt Foundation, Germany, and the Robert A. Welch Foundation, Texas. He has conducted research at MD Anderson Cancer Center in Houston, University of California at Irvine, University of Freiburg in Germany, etc., and taught at the University of California, Irvine and the University of Medicine and Dentistry of New Jersey. Dr. Rajasekhar has served as a peer reviewer for several journals, including Stem Cells, Proceedings of National Academy of Sciences USA, Journal of Molecular Biology, Journal of Cell Biology, Neoplasia, etc.
Klappentext
Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back at least epigenetically into non-tumor forming cells.
The book builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.
"This book is both an elegant review and a practical guide to the exciting, and still largely uncharted, world of cancer stem cells. I praise the editor and the authors for this wonderful endeavor, rich of provocative ideas and challenging concepts, not only for a better understanding of basic cancer biology, but also for the future development of new, more effective, anti-tumor treatments."
Michael F. Clarke, MD., Stanford University
"This authoritative book, written by a range of world-leading cancer researchers, provides a comprehensive overview of the cancer stem cell, its microenvironment, and how these insights will lead to novel clinical strategies."
Hans Clevers, MD., PhD., Hubrecht Institute, Utrecht
"For those wanting to stay abreast of the field from a basic as well as a clinical perspective, this book will be a welcome read and resource."
Connie J. Eaves, PhD., FRSC., Terry Fox Laboratory, Vancouver
"This volume reports on many aspects of these cells in a variety of human tumors, justifying the notion that CSCs are likely to be important players in virtually all types of human tumors."
Robert A. Weinberg, PhD., Whitehead Institute, Massachusetts Institute of Technology
Zusammenfassung
Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic.
Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.
Inhalt
About the Editor xi
Contributors xiii
Foreword xxi
Preface xxiii
Acknowledgments xxxv
Section I Essentials of Cancer Stem Cells and Conceptual Modeling 1
1 Theoretical and Experimental Foundations of the "Cancer Stem Cell" Model 3
Pradeep S. Rajendran and Piero Dalerba
2 The Hallmarks of Prostate Cancer Stem Cells 17
Norman J. Maitland and Anne T. Collins
3 Self-Renewal, Induced Proliferation, and Autonomous Cell Growth Represent Distinct Modes of Cell Multiplication: Relevance to the Cancer Stem Cell Theory 39
Dov Zipori
4 Human Embryonic Stem Cells and Cancer: Modeling Disease in a Dish 49
Tamra Werbowetski-Ogilvie and Robyn McClelland
5 Cancer Stem Cell as a Result of a Reprogramming-Like Mechanism: Implications in Tumor Development and Treatment 61
J.M. Iglesias, Idoia Garcia-Ramirez, Alberto Martin-Lorenzo, L. Vellon, Lucia Ruiz-Roca, A.G. Martin, and Isidro Sanchez-Garcia
6 A Cancer Stem Cell Model: An Insight into the Conversion of Induced Pluripotent Stem Cells to Cancer Stem-Like Cells 79
Akifumi Mizutani, Ling Chen, Tomonari Kasai, Takayuki Kudoh, Hiroshi Murakami, Li Fu, and Masaharu Seno
7 Altruistic Stem Cells and Cancer Stem Cells 89
Bikul Das
8 The Emerging Concept of EMT-Induced Cancer Stem Cells 107
Jeremy Bastid
9 Models to Study Chronic Myeloid Leukemia Cancer Stem Cells 119
Sheela A. Abraham, Lisa Hopcroft, Ravi Bhatia, Steffen Koschmieder, Anthony D. Whetton, and Tessa L. Holyoake
10 Cancer Stem Cells in Melanoma: Biomarkers and Mathematical Models 133
Stefano Zapperi and Caterina A.M. La Porta
Section II Stem Cells in Liquid Tumors 143
11 Acute Myeloid Leukemia Stem CellsUpdates and Controversies 145
Stephen S. Chung and Christopher Y. Park
12 Leukemia-Initiating Cells in Acute Lymphoblastic Leukemia 161
Thorsten Raff and Monika Brüggemann
Section III Stem Cells in Solid Tumors 171
13 Lung Cancer Stem Cells and Resistance to Radiotherapy 173
Scott V. Bratman and Maximilian Diehn
14 Prostate Cancer Cell Heterogeneity and Prostate Cancer Stem Cells 183
Mark A. Badeaux and Dean G. Tang
15 Glioblastoma Stem Cells Drive Tumor Recurrence and Patient Relapse: What's the Evidence? 193
Aneet Mann, Randy van Ommeren, Branavan Manoranjan, Nicole McFarlane, Parvez Vora, Chitra Venugopal, and Sheila Singh
16 Stem Cells and Pancreatic Cancer 209
Susana Garcia-Silva and Christopher Heeschen
17 Melanoma Subpopulations with Cancer Stem Cell Phenotypes 223
Rajasekharan Somasundaram, Nicole Facompre, and Meenhard Herlyn
18 Sarcoma Stem Cells 235
Filemon S. Dela Cruz and Igor Matushansky
Section IV Cancer Stem Cells in Tumor Metastasis Perspective 247
19 Cancer Stem Cells in Metastasis and Minimal Residual Disease 249
Joerg Huelsken and Albert Santamaria i Martinez
20 Role of Cancer Stem Cells in Metastasis 259
Giovanna Merchand-Reyes, Rosana Pelayo, Lenin Pavón, Richard G. Pestell, and Marco Velasco-Velázquez
21 Cancer Stem Cells and the Stromal Microenvironment 2…