New developments in Systems Biology, OMICS-es, Synthetic Biology, Bioinformatics, Automatics, Computer Science, and some crossdisciplinary fields like Cognitive Science, Artificial Intelligence for dealing with biological applications, are morphing into a new subject: Integrated Biotechnology. Integrated Biotechnology focuses strongly on the high level "global behavior" of complex systems, which is considered to be more holistic than reductionistic. Integrated Biotechnology is an interdisciplinary in biotechnology that integrates various disciplines, including genetic engineering, cell culture, bioseparation, mathematics and modeling, bioinformatics, etc, and techniques related to up-, mid-, and down-stream biotechnology, into new one to produce or modify biological products or processes for improving people's living standards. Integrated biotechnology is unique in bringing together a wide range of scientists, technologists and engineers from so many disciplines as biology, molecular biology, genetics, microbiology, bioinformatics, mathematics and modeling, bioseparation, computer science, engineering principles and so on, particularly in the application of holistic strategy of the up-, mid-, and down-stream biotechnology. This book provides readers with guidance on how to study a complex biological system by taking integrative strategy and how to apply integrated biotechnologies to obtain biological products with some successful examples. Equipped with the knowledge about the foundations and tools of integrated biotechnology, it will become practicable for us to do optimal design and development of bioprocesses from upstream to downstream. This book is a comprehensive textbook of modern biotechnology, the intended readers are graduate students plus academic and professional researchers of life science, medical science, environmental science, food science, agricultural science, bioengineering and biotechnology and so on.