Written in an accessible style and consistent format, the book
covers both the fundamentals and advances in the pharmacology of
cardiovascular drugs, as well as their integrated applications in
the management of individual cardiovascular diseases.
* Integrates fundamentals and recent
advances regarding cardiovascular drugs, blending basic and
clinical sciences needed to effectively understand and treat
cardiovascular diseases
* Facilitates understanding of drug action
and mechanism by covering physiology / pathophysiology and
pharmacology
* Includes guidelines and algorithms for
pharmacotherapeutic management of cardiovascular diseases
* Uses case presentations and study
questions to enhance understanding of the material
* Serves as a resource for pharmaceutical
and medical students and researchers interested in cardiovascular
issues
Autorentext
Y. Robert Li is Professor and Founding Chair of the Department of Pharmacology and Assistant Dean for Biomedical Research at Campbell University and holds Adjunct Professor appointments at Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Virginia-Maryland Regional College of Veterinary Medicine, and University of North Carolina at Greensboro. He is an author of over 110 peer-reviewed publications, three monographs, and numerous book chapters and serves on the editorial boards of several leading journals. Dr. Li has over 20 years of teaching experience in the areas of biomedical sciences, free radical biology, toxicology, pharmacology, and therapeutics.
Klappentext
Even though there has been improvement in treatment and significant reduction in mortality rate, cardiovascular disease remains one of the leading causes of death around the world. Drug therapy continues to rank high as a way to manage heart disease making cardiovascular pharmacology a key part of medical education and drug development research.
This book addresses the needs of these students and researchers by systematically integrating essentials, advances, and clinical correlations for cardiovascular drugs. The author, who has over two decades of experience teaching this topic, covers both the fundamentals and most recent advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases. In addition, the text presents evidence-based pharmacotherapeutics in the management of common cardiovascular diseases and conditions that include dyslipidemias, hypertension, ischemic heart disease, heart failure, cardiac arrhythmias, and ischemic stroke.
Written in an accessible style and consistent format, the book covers both the fundamentals and advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases.
• Blends basic and clinical sciences needed to effectively understand and treat cardiovascular diseases
• Facilitates understanding of drug action and mechanism by covering physiology / pathophysiology and pharmacology
• Includes guidelines and algorithms for pharmacotherapeutic management of cardiovascular diseases
• Uses case presentations and study questions to enhance understanding of the material
• Serves as a resource for pharmaceutical and medical students and researchers interested in cardiovascular issues
Zusammenfassung
Written in an accessible style and consistent format, the book covers both the fundamentals and advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases.
• Integrates fundamentals and recent advances regarding cardiovascular drugs, blending basic and clinical sciences needed to effectively understand and treat cardiovascular diseases
• Facilitates understanding of drug action and mechanism by covering physiology / pathophysiology and pharmacology
• Includes guidelines and algorithms for pharmacotherapeutic management of cardiovascular diseases
• Uses case presentations and study questions to enhance understanding of the material
• Serves as a resource for pharmaceutical and medical students and researchers interested in cardiovascular issues
Inhalt
PREFACE xix
LIST OF ABBREVIATIONS xxii
UNIT I GENERAL INTRODUCTION 1
1 Introduction to Cardiovascular Diseases 3
1.1 Overview 3
1.2 Definition of Cardiovascular Diseases 3
1.3 Classification of Cardiovascular Diseases 3
1.4 Prevalence, Incidence, and Trend of Cardiovascular Diseases 5
1.5 Risk Factors of Cardiovascular Diseases 9
1.6 Prevention and Control of Cardiovascular Diseases 10
1.7 Cardiovascular Risk Prediction and Evidence?]Based Treatments 15
1.8 Summary of Chapter Key Points 18
1.9 Self-Assessment Questions 18
References 19
2 Introduction to Principles of Pharmacology 21
2.1 Overview 21
2.2 Definitions and History 21
2.3 Pharmacological Paradigm: the Central Dogma in Pharmacology 24
2.4 Principles of Drug Discovery, Development, and Regulation 31
2.5 Pharmacology Subspecialties 32
2.6 Introduction to Cardiovascular Pharmacology 32
2.7 Summary of Chapter Key Points 38
2.8 Self?]Assessment Questions 39
References 40
UNIT II DYSLIPIDEMIAS 43
3 Overview of Dyslipidemias and Drug Therapy 45
3.1 Introduction 45
3.2 Lipoprotein Metabolism 45
3.3 Dyslipidemias and Genetic Lipoprotein Disorders 51
3.4 Mechanistically Based Drug Therapy of Dyslipidemias 51
3.5 Summary of Chapter Key Points 53
3.6 Self?]Assessment Questions 54
References 54
4 Drugs for Dyslipidemias 56
4.1 Overview 56
4.2 Statins 56
4.3 Bile Acid Sequestrants 64
4.4 Cholesterol Absorption Inhibitors 69
4.5 Fibrates 72
4.6 Niacin 75
4.7 New Drugs for HoFH 80
4.8 Phytosterols and Phytostanols 83
4.9 Omega?]3 Fatty Acids 86
4.10 Emerging Therapeutic Modalities for Dyslipidemias 88
4.11 Summary of Chapter Key Points 93
4.12 Self-Assessment Questions 93
References 95
5 Management of Dyslipidemias: Principles and Guidelines 99
5.1 Overview 99
5.2 General Principles of the Management of Dyslipidemias 99
5.3 Current Evidence?]Based Guidelines on the Management of Dyslipidemias 102
5.4 Summary of Chapter Key Points 113
5.5 Self?]Assessment Questions 113
References 114
UNIT III HYPERTENSION AND MULTITASKING CARDIOVASCULAR DRUGS 117
6 Overview of Hypertension and Drug Therapy 119
6.1 Introduction 119
6.2 Definitions, Classifications, and Epidemiology of Hypertension 119
6.3 Pathophysiology of Hypertension 121
6.4 Mechanistically Based Drug Therapy of Hypertension: An Overview 123
6.5 Summary of Chapter Key Points 123
6.6 Self?]Assessment Questions 125
References 125
7 Diuretics 127
7.1 Overview 127
7.2 Volume Regulation and Drug Targeting 127
7.3 Thiazide and Thiazide?]Type Diuretics 129
7.4 Loop Diuretics 134
7.5 Potassium?]Sparing Diuretics 138
7.6 Other Diuretics 142
7.7 Summary of Chapter Key Points 143
7.8 Self?]Assessment Questions 143
References 144
8 Sympatholytics 147
8.1 Overview 147
8.2 Sympathetic Nervous System and Drug Targeting 147
8.3 ?]Adrenergic Receptor Antagonists 150
8.4 ?]Adren…