Post Genomics Drug Discovery and Research explores and discusses
some of the most important topics in post-genomics life and
biopharmaceutical sciences. It provides an introduction to the
field, outlining examples of many techniques currently used, as
well as those still under development, which are important for the
research of biopharmaceutical discovery in the post-genomics era.
* Integrates several developing and cutting-edge technologies and
methods like bioinformatics, experimental therapeutics, and
molecular recognition
* Includes discussion on topics such as: computer-aided ligand
design; peptide and protein chemistry and synthesis; synthesis of
active natural products; and the use of emerging technologies like
proteomics, nanotechnology, or bioengineering.
Autorentext
Ziwei Huang, PHD, is Professor at the Burnham Institute for Medical Research and Adjunct Professor at the University of California at San Diego. He was previously Assistant Professor at Thomas Jefferson University in Philadelphia (1995-2000) and tenured Associate Professor at the University of Illinois at Urbana-Champaign (2000-2004). The author or coauthor of numerous publications and patents, Professor Huang has conducted research in cross-disciplinary areas related to drug discovery, medicinal chemistry, biochemistry, and chemical biology and has developed novel therapeutic agents and research probes for treating or studying human diseases. He has organized many international conferences and workshops in drug discovery research in America and Asia. Additionally, Professor Huang has had close interaction with the biotechnology and pharmaceutical industries as the founder of several biopharmaceutical companies and consultant for many major biotechnology and pharmaceutical companies.
Klappentext
Leading-edge research and technologies that facilitate drug discovery
This definitive compilation of information on current drug discovery research reviews?some of the most important topics in post-genomic?biomedical and biopharmaceutical science, such as pharmacogenomics, structure-based drug design, medicinal chemistry, chemical biology, cancer biology, neuroscience, bio-nanotechnology, and stem cell research.
Including a Foreword by the late Nobel laureate Paul C. Lauterbur, and with contributions from seventy scholars and researchers from around the world, this book incorporates a general introduction to and practical examples of some of the many methods and techniques for the research of biopharmaceutical discovery in the post-genomic era. The contributors include experts in chemistry, structural biology, computation, biology, and medicine who have a common interest in translating research discoveries into new human therapies. In addition to exploring recent advances, they share their perspectives on various aspects of drug discovery research in the future.
Drug Discovery Research: New Frontiers in the Post-Genomic Era is a hands-on resource for practitioners and researchers in the pharmaceutical field and related industries, as well as a valuable reference for students in pharmaceutical science, chemistry, biology, biophysics, bioengineering, pharmacy, and medicine.
Zusammenfassung
Post Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era.
- Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition
- Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering.
Inhalt
FOREWORD.
INTRODUCTION.
CONTRIBUTORS.
PART I. COMPUTATIONAL AND STRUCTURAL APPROACHES IN DRUG DISCOVERY.
CHAPTER 1. MOLECULAR DOCKING AND STRUCTURE-BASED DESIGN (P. Therese Lang, University of California, San Francisco, CA; Tiba Aynechi, University of California, San Francisco, CA; Demetri Moustakas, University of California, Berkeley, CA; Brian Shoichet, Irwin D. Kuntz,* University of California, San Francisco, CA; Natasja Brooijmans, University of California, San Francisco, CA; and Connie M. Oshiro, Roche, Palo Alto, CA).
CHAPTER 2. RECENT ADVANCES IN DRUG DISCOVERY RESEARCH USING STRUCTURE-BASED VIRTUAL SCREENING TECHNIQUES: EXAMPLES OF SUCCESS FOR DIVERSE PROTEIN TARGETS (Sutapa Ghosh (Burnham Institute for Medical Research La Jolla, CA), Aihua Nie (Burnham Institute for Medical Research La Jolla, CA), Jing An (Burnham Institute for Medical Research La Jolla, CA), and Ziwei Huang* (University of California, San Diego; Burnham Institute for Medical Research La Jolla, CA).
CHAPTER 3. VIRTUAL SCREENING IN DRUG DISCOVERY (Malcolm J. McGregor, Zhaowen Luo, and Xuliang Jiang* (Serono Research Institute, Rockland, MA).
CHAPTER 4. COMPUTER-AIDED DRUG DESIGN (Grace Shiahuy Chen, Providence University, Shalu, Taiwan, Republic of China and Ji-Wang Chern,* National Taiwan University, Taipei, Taiwan, Republic of China).
CHAPTER 5. FOCUSED LIBRARY DESIGN BASED ON HIT AND TARGET STRUCTURES: METHOD AND APPLICATION IN DRUG DISCOVERY (Weiliang Zhu (Shanghai Institute ofMateriaMedica, Chinese Academy of Sciences, Shanghai, P.R. China), Jian Li (Shanghai Institute ofMateriaMedica, Chinese Academy of Sciences, Shanghai, P.R. China), Zhen Gong (Shanghai Institute ofMateriaMedica, Chinese Academy of Sciences, Shanghai, P.R. China), Hong Liu (Shanghai Institute ofMateriaMedica, Chinese Academy of Sciences, Shanghai, P.R. China), and Hualiang Jiang* (Shanghai Institute ofMateriaMedica, Chinese Academy of Sciences, Shanghai, P.R. China, East China University of Science and Technology, Shanghai, P.R. China).
PART II. CHEMICAL AND SYNTHETIC APPROACHES IN DRUG DISCOVERY.
CHAPTER 6. BEYOND NATURAL PRODUCTS: SYNTHETIC ANALOGUES OF BRYOSTATIN 1 (Paul A. Wender*, Jeremy L. Baryza, Michael K. Hilinski, Joshua C. Horan, Cindy Kan, and Vishal A. Verma (Stanford University, Stanford, CA).
CHAPTER 7. THE PROMISES AND PITFALLS OF SMALL-MOLECULE INHIBITION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) (Amanda C. Nottbohm and Paul J. Hergenrother* (University of Illinois at Urbana-Champaign, Urbana, IL).
CHAPTER 8. CYCLIC ADP-RIBOSE ANALOGUES WITH MINIMAL STRUCTURE: SYNTHESIS AND CALCIUM-RELEASE ACTIVITY (Lihe Zhang* (Peking University, Beijing, P.R. China) and Andreas H. Guse (University Hospital HamburgEppendorf, Institute of Biochemistry and Molecular Biology, Hamburg, Germany).
CHAPTER 9. EVALUATION OF NEUROIMMUNOPHILIN LIGANDS (Junhai Xiao, Aihua Nie, and Song Li* (Beijing Institute of Pharmacology and Toxicology, Beijing, P.R. China).
CHAPTER 10. CHIRAL DRUGS AND THE ASSOCIATED ASYMMETRIC SYNTHESIS (Jiange Zhang (Zhengzhou University, Zhengzhou, P.R. China) and Guoqiang Lin* (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P.R. China).
CHAPTER 11. ALPHA-HELIX MIMETICS IN DRUG DISCOVERY 281
Hang Yin, Gui-In Lee, and Andrew D. Hamilton*
Yale University, New Haven, CT
CHAPTER 12. BASIC AND TRANSLATIONAL RESEARCH OF CHEMOKINE LIGANDS AND RECEPTORS AND DEVELOPMENT OF NOVEL THERAPEUTICS (Won-Tak Choi, University of Illinois at Urbana-Champaign, Urbana, IL; Yohichi Kumaki, Raylight Corporation, Chemokine Pharmaceutical Inc., La Jolla, CA; I. M. Krishna Kumar, Burnham Institute for Medical Research, La…