This issue of Emergency Medicine Clinics, guest edited by Drs. Angela Mills and Anthony Dean, will include articles on the following topics: Approach to acute abdominal pain;Evaluation of abdominal pain in older adults; Evaluation of abdominal pain in the pediatric population; Imaging and laboratory testing in acute abdominal pain;Esophageal and gastric emergencies; and Anorectal emergencies and foreign bodies in the gastrointestinal tract.