Principles and Practice of Clinical Virology is the bible
for all working in the field of clinical virology - from the
trainee to the expert because there's always something new to
learn! As before, the book provides a detailed account of the
diagnosis and treatment of virus infections, with a stronger
emphasis on clinical expertise and management. Each chapter deals
with a single virus or group or viruses and is written by leading
international experts in the field.
What's new in this edition ...
* Showcases the wealth of new knowledge acquired on virus
infections and reflects the discovery of newly recognized emerging
infections, the improvement or development of new vaccines, and an
increasing repertoire of antiviral agents for treatment
* All chapters have been thoroughly revised and there are a
number of new contributors, joining the cadre of
internationally-recognized experts
* Includes a new chapter on vaccinology covering the principles
relating to the development and use of vaccines generally, which
complements the specific vaccines described in the other
chapters
* The two chapters on nosocomial infections have been enlarged
and will be particularly useful for those having to advise on the
management of hospital-acquired infections
* Emphasizes the rapid accumulation of new information in such
fields as retroviruses, particularly HIV, SARS, hepatitis C and
influenza, including avian influenza
Autorentext
ARIE J. ZUCKERMAN, Royal Free Hospital, UK.
JANGU E. BANATVALA, Emeritus Professor of Clinical Virology, Guy's King's and St Thomas' School of Medicine and Dentistry, London, UK.
PAUL D. GRIFFITHS, Royal Free & University College Medical School, London, UK.
BARRY SCHOUB, National Institute for Communicable Diseases, Sandringham, South Africa.
PHILIP MORTIMER is the editor of Principles and Practice of Clinical Virology, 6th Edition, published by Wiley.
Zusammenfassung
Principles and Practice of Clinical Virology is the bible for all working in the field of clinical virology from the trainee to the expert because there's always something new to learn! As before, the book provides a detailed account of the diagnosis and treatment of virus infections, with a stronger emphasis on clinical expertise and management. Each chapter deals with a single virus or group or viruses and is written by leading international experts in the field.
What's new in this edition
- Showcases the wealth of new knowledge acquired on virus infections and reflects the discovery of newly recognized emerging infections, the improvement or development of new vaccines, and an increasing repertoire of antiviral agents for treatment
- All chapters have been thoroughly revised and there are a number of new contributors, joining the cadre of internationally-recognized experts
- Includes a new chapter on vaccinology covering the principles relating to the development and use of vaccines generally, which complements the specific vaccines described in the other chapters
- The two chapters on nosocomial infections have been enlarged and will be particularly useful for those having to advise on the management of hospital-acquired infections
- Emphasizes the rapid accumulation of new information in such fields as retroviruses, particularly HIV, SARS, hepatitis C and influenza, including avian influenza
Inhalt
List of Contributors.
Preface.
Past, Present and Future of Clinical Virology: An Overview.
1 Diagnostic Approaches (Katie Jeffery and Emma Aarons).
Introduction.
Electron Microscopy.
Histology/Cytology.
Virus Isolation.
Serology.
Molecular Amplification Techniques.
Recommended Diagnostic Investigations.
Future Trends.
2 Viral Transmission: Infection Acquired by the Blood-borne Route (Will Irving).
Introduction.
Prevention of Exposure through Infection Control.
Prevention of Infection through Specific Pre- and Post-exposure Policies.
Patient-to-patient Transmission.
Patient-to-HCW Transmission.
HCW-to-patient Transmission.
3 Viral Transmission: Infection Acquired by All Other Routes (Respiratory, Eye-Nose-Mouth, Inoculation and Faeco-orally) (Philip Rice).
Introduction.
Measles, Mumps and Rubella.
Cytomegalovirus.
Varicella Zoster Virus.
Herpes Simplex Virus.
Noroviruses.
Rotavirus.
Parvovirus B19.
Respiratory Viruses.
4 Emerging Virus Infections (Brian W.J. Mahy).
Introduction.
Factors Contributing to Emergence.
Future Directions.
5 Vaccinology (Francis E. Andre and Hugues H. Bogaerts).
Introduction.
Burden of Viral Diseases and their Reproductive Rates.
The Immune System and its Role in Natural and Artificially-induced Immunity.
Discovery of Protective Antigens in Pathogens.
Presentation of Protective Antigens through Vaccines and Types of Vaccine.
Research and Development on Vaccines and their Commercial Introduction.
Social Marketing of Introduced Vaccines.
Planning and Implementation of Vaccination Programmes.
Surveillance of Disease Incidence and Adverse Events Before and After Implementation of Vaccination.
Rectification of Publicized Falsehoods and Maintenance of Vaccination Coverage.
Viral Vaccines on the Horizon and the Roadblocks to Future Vaccine Development.
Closing Comments.
6 Herpes Simplex Virus Type 1 and Type 2 (Marianne Forsgren and Paul E. Klapper).
Morphology.
Replication.
Epidemiology.
Viral Diagnosis.
Antiviral Chemotherapy.
Clinical Features, Diagnosis and Management.
Concluding Remarks.
7 Varicella Zoster (Judith Breuer).
Introduction.
The Virus.
Epidemiology.
Clinical Features.
Diagnosis of VZV Infection.
Treatment.
Prevention.
8 Cytomegalovirus (Paul D. Griffiths).
Introduction.
The Virus.
Epidemiology.
Routes of Infection.
Pathogenesis.
Clinical Features.
Diagnosis.
Management.
Prevention.
Treatment.
9 Epstein-Barr Virus (Tanzina Haque and Dorothy H. Crawford).
Introduction.
The Virus.
Epidemiology.
EBV-associated Diseases.
EBV Infection in the Immunocompromized Host.
Vaccine Development.
10 Roseoloviruses: Human Herpesviruses 6A, 6B and 7 (Katherine N. Ward and Duncan A. Clark).
Introduction.
Biology of the Viruses.
Epidemiology and Pathogenesis.
Disease Associations.
Laboratory Diagnosis.
Antiviral Therapy.
Concluding Remarks.
11 Kaposi's Sarcoma-associated Herpesvirus (Human Herpesvirus 8) (Cornelia Henke-Gendo, Abel Viejo-Borbolla and Thomas F. Schulz).
Introduction.
Origin and Evolution of KSHV.
Worldwide Distribution of KSHV in the General Population.
Transmission.
Clinical Manifestations.
Pathogenesis.
Diagnostic Assays.
Antiviral Therapy.
12 Hepatitis Viruses (Tim J. Harrison, Geoffrey M. Dusheiko and Arie J. Zuckerman).
Introduction.
Hepatitis A.
Hepatitis E.
Hepatitis B.
Hepatitis D.
Hepatitis C.
13 GB Virus C (GBV-C) and Torque Teno Virus (TTV) (Shigeo Hino).
Introduction.
GB Virus C (GBV-C).
Torque Teno Virus (TTV).
14 Rotaviruses (Ulrich Desselberger and Jim Gray).
Introduction.
Rotavirus Structure, Genome and Gene-Protein Assignment.
Classification.
Rep…