Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitochondrial genes, and their role in immunity against various disease states in animal models. This title also discusses the role of nuclear genes involved in mitochondrial function, as well as numtogenesis and its role in immune function. It provides a holistic introduction to the study of mitochondrial genomics, or mitogenomics. Co-authored by two experts in mitochondrial determinants of health, early chapters describe the structural organization of mitochondria and mitochondrial genetics using different animal models. Central chapters discuss the role of mitogenomics in metabolic, viral, bacterial, and parasitic diseases, fungal infestations, neurodegenerative disorders, and cancer. The book concludes with the prospects of studying mitochondrial genes using next generation sequencing and the various methodologies for correction of genetic defects in mitochondria. Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases offers a strong foundation for academic researchers, industry scientists, and students interested in disease resistance, immunology, and mitogenomics. - Introduces mitochondrial genetics and function using animal models - Discusses the role of mitogenomics in various disease states - Considers the implication of whole mitochondrial genome sequencing in animals - Explores mitochondrial replacement theory and gene editing
Autorentext
Dr. Aruna Pal is Assistant Professor at West Bengal University of Animal and Fishery Sciences (WBUASFSCI). She obtained her MVSc at the National Dairy Research Institute, India, and her PhD in Animal Genetics and Breeding at the Indian Veterinary Research Institute. She has acted as Convenor for the Human Genetics and Genomics Task Force for India's Ministry of Science and Technology and currently heads the Animal Genomics lab for WBUASFSCI's Department of Animal Genetics and Breeding. Her research focuses on mitochondrial genetics and diseases using animal models. She has authored multiple books, including Elsevier's Genetics and Breeding for Disease Resistance of Livestock.Dr. Keshav Singh is Professor of Genetics and Endowed Chair within the University of Alabama at Birmingham's Genetics Research Division. He obtained his MSc in India, PhD in Australia, and postdoctoral studies at Harvard University. He is a leader in the field of mitochondrial determinants of health, disease, diversity, and health disparities. He is the founding Editor-in-Chief of Elsevier's Mitochondrion journal, founder of the Mitochondria Research and Medicine Society (USA), and founder of the Society for Mitochondrial Research and Medicine (India).