Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.



Autorentext

Dr. Basavarajaiah D. M. working as an Associate Professor and Head, Department of Statistics and Computer Science, Karnataka Veterinary Animal and Fisheries Sciences University (B), Hebbal, Bangalore. He obtained Ph.D from National Institute of Epidemiology (NIE), ICMR, Chennai, (affiliated from University of Madras).His area of research heeds Statistical theory, Statistical modeling on high dimensional datasets of Agriculture, Medicine, Veterinary and animal Sciences. He penned seventy research articles and seven academic books published in national and reputed International publishers (Springer nature group). Serving as an editorial Board Member and Scientific Board advisor of various International indexed journals. Life Member of numerous academic organizations. Honoured several accolades for his academic and research Excellency Chartered Scientist award stalwart by Science Council, United Kingdom in Collaboration with Royal Statistical Society. Best Reviewer award -2016'TRANS STELLAR' Journal Publications and Research Consultancy, TJPRC Ltd., (NAAS rated Journals), Fellow of Royal Statistical Society ,UK (London), Fellow of Mathematical Society ,UK (London), Bharathshikshratana and Indo-Dubai Achiever's Pacific award honoured by Global Society of health and educational growth new Delhi, Best reviewer-2015, Best Scientific Board advisor - 2016 and Best editorial and researcher award bestowed by International academy of Engineering Science and technology, USA. He delegate power as an active member of Board of Studies and Academic Council of various Universities.

Professsor Narasimha Murthy is a well-known academician and researcher, Former Scientist 'G' (Director Grade cadre), National Institute of Epidemiology of ICMR, Chennai. Now, National Level Monitor, National Health Mission, MOH&FW, Government of India. He obtained PhD from International Institute for Population Science (IIPS), affiliated to Bombay University (1985). His areas of research are mainly Mathematical Statistics, Operational research, Clinical research, Public health, Demography and Vital Statistics, Mathematical modeling with respect to Medical Science and Public health. He penned more than 100 research articles published in reputed National and International Journals.  Serving as an editorial Board Member and Scientific Board advisor of various International indexed MCI and UGC recognized journals. Life Member of various academic organizations and professional societies. He honoured several accolades for his academic and research Excellency viz Prof. R. N. Srivastava gold medal award, 'Bharat Jyothi Award', 'Best Citizens of India award etc. He serves as a member of Board of Studies of various National Universities (University of Madras, Acharya Nagarjuna University &University of Kerala) and also a visiting emeritus Professor of Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, North Carolina University USA, etc. Reviewer of National and International Journals.



Zusammenfassung

Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.



Inhalt
1Design of Clinical Research and its Practical approach..............................................................
1.1Introduction..
1.2 Statistical Historical Perspectives of Clinical trail.. 
1.2.1 Global mile stone.
1.2.2 Indian mile stone
1.3 Clinical research
1.3.1 Intervention.
1.3.2 Non intervention
1.4Types of clinical research.
1.4.1 Patient oriented research
1.4.2 Epidemiological and behavioral studies 
1.4.3 Out come and health related services research.. 
1.5Risk in clinical research
1.6 Clinical trial.
1.6.1 Treatment trial
1.6.2 Prevention trial..
1.6.3 Quality of life trial
1.6.4 Diagnostic trial ..
1.7Glossary..
1.8 Brief concept of study design.
1.9 Experimental study.
1.9.1 Randomized controlled trail (RCT)
1.9.2 Non Randamized controlled trail (RCT).
1.10 Randomization study.
1.10.1 Salient Properties of Randamizatin.
1.11 Non randomization ..
1.11.1 Cohort study.
1.11.2 Selection of study subjects
1.11.3 Carrying out research on special populations..
1.11.4 Justice.
1.11.5 Obtaining data sets on exposure.
1.11.6 Selection of comparison ..
1.11.7 Follow up record.
1.11.8Compilation and inference
1.11.9 Strength of cohort study
1.11.10 Weakness of Cohort study design
1.12Cross sectional study..
1.13 Longitudinal study
1.14Prospective study.
1.15 Retrospective study: case control..
1.16Case control study..
1.17 Different phases of clinical trial..
1.18  Study population..
1.19  Statistical issues and methods..
1.20Application of multinomial distribution in clinical trial.
1.…
Titel
Design of Experiments and Advanced Statistical Techniques in Clinical Research
EAN
9789811582103
Format
E-Book (pdf)
Veröffentlichung
05.11.2020
Digitaler Kopierschutz
Wasserzeichen
Dateigrösse
17.67 MB
Anzahl Seiten
356