Two Cowboys in New York, is the story of what happens when two cowboys come for a friend's wedding in the big city and find that the bride's father has disappeared. They offer to try to find out what happened to him after he left a meeting at the Port of New York, and they become entangled with the New York's Mafia who were robbing passengers at the port.

The Mafia never before in their history ran into adversaries like these two cowboys. Indian Leader and Rocky Stone just don't play by the same rules that the Mafia was used to facing.

Can Indian and Rocky find the bride's father and let their friend's wedding finally happen and corral the Mafia at the same time?