The observation and manipulation of individual molecules is one of the most exciting developments in modern molecular science. Single Molecule Science: Physical Principles and Models provides an introduction to the mathematical tools and physical theories needed to understand, explain, and model single-molecule observations. This book explains the

Dmitrii E. Makarov is a professor of chemistry at the University of Texas at Austin. He earned a PhD in theoretical physics from the Institute of Chemical Physics in Moscow. His expertise is in theoretical and computational chemical physics and in biophysics.

A Brief History of Thought and Real Single-Molecule Experiments. How the Properties of Individual Molecules Are Measured. The Kinetics of Chemical Reactions: Single-Molecule Versus "Bulk" View. How Molecules Explore their Energy Landscapes. Microscopic View of the Rate of a Chemical Reaction: A Single-Molecule Perspective. Molecular Transition Paths: Why Going Uphill May Be Faster. Properties of Light Emitted by a Single Molecule and What It Can Tell Us About Molecular Motion. Single-Molecule Mechanics. Nonequilibrium Thermodynamics of Single Molecules: The Jarzynski and Crooks Identities. Single-Molecule Phenomena in Living Systems. Appendix A Probability Theory, Random Numbers and Random Walks. Appendix B Appendix B: Elements of Statistical Mechanics.