In this chapter, we discuss principles of cognitive-behavioral therapy (CBT) for panic disorder. We begin by describing the presentation of panic disorder (PD) from a cognitive-behavioral perspective, then examining the evaluation and assessment of PD, and then examining the treatment components of CBT for PD. We detail treatment plans, goal formation, and agenda setting. Finally, we review empirical support for this treatment and future directions in the treatment of PD. The chapter concludes with a case vignette illustrating how CBT can be used to treat panic disorder.