The application of systems biology methods to Traditional Chinese Medicine Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature. Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development. Using three popular traditional Chinese medicines--Shuanglongfang, Qingkailing, and Liushenwan--as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also: * Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics * Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies * Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities * Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.
Autorentext
GUOAN LUO is Professor in the Institute of Biomedicine and Director of the Modern Research Center for Traditional Chinese Medicine at Tsinghua University in Beijing. Professor Luo is dedicated to the application of systems biology to study and advance TCM. He has published more than 680 peer-reviewed papers and applied for thirty-one patents. Among the many honors he has received for his research achievements are two National Scientific and Technological Advancement Prizes.
YIMING WANG is Professor at Tsinghua University.
QIONGLIN LIANG is Associate Professor at Tsinghua University.
QINGFEI LIU is Assistant Professor at Tsinghua University.
Klappentext
The application of systems biology methods to Traditional
Chinese Medicine
Emphasizing the harmony of the human body with the environment,
Traditional Chinese Medicine (TCM) has evolved over thousands of
years. It is a systemic theory derived from clinical experience,
the philosophy of holism and systematology, and the belief that man
is an integral part of nature.
Systems Biology for Traditional Chinese Medicine
describes how the latest methods in systems biology can be applied
to TCM, providing a comprehensive resource for the modernization
and advancement of TCM as well as general drug discovery efforts.
It is the first comprehensive work to propose a system-to-system
research methodology to study the interaction between TCM and the
human body and its applications in drug research and
development.
Using three popular traditional Chinese
medicines--Shuanglongfang, Qingkailing, and
Liushenwan--as examples, the authors set forth case examples
demonstrating how to find material groups, perform efficacy
screenings, and conduct safety evaluations of TCM. The book
also:
* Describes the mechanisms of TCM at the molecular and systems
levels using chemomics, genomics, proteomics, metabolomics, and
bioinformatics
* Places modern scientific technologies within the context of
TCM, helping drug researchers improve experimental designs and
strategies
* Illustrates how a systems biology approach is compatible with
TCM's traditional, holistic therapeutic strategies and treatment
modalities
* Presents topics of current interest, such as integrated global
systems biology and the application of chemometrics research to
herbal medicines
This book not only opens a new pathway for the continued
development of TCM, but also for systems biology. In addition, it
fosters collaboration and discussion among Eastern and Western
scientists by applying systems biology to TCM.
Zusammenfassung
The application of systems biology methods to Traditional Chinese Medicine
Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature.
Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development.
Using three popular traditional Chinese medicinesShuanglongfang, Qingkailing, and Liushenwanas examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also:
- Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics
- Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies
- Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities
- Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines
This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.
Inhalt
Foreword ix
Preface xiii
Abbreviations xvii
1 Introduction of Systems Biology in Traditional Chinese Medicine (tcm) 1
1.1 Characteristics and Compatibility Principles of Traditional Chinese Medicine (TCM) 1
1.2 Key Scientific Issues in TCM Modernization 9
1.3 Development of Systems Biology 16
1.4 Chemomics Integrated Systems Biology 19
1.5 Research Strategy and Prospective of Systems Biology in Tcm 25
References 34
2 Chemomics of Traditional Chinese Medicine 38
2.1 Characteristics and Research Difficulties in TCM 39
2.2 Background of TCM Chemomics' Proposal and Development 45
2.3 Chemomics 52
2.4 Chemomics and the Research of Formulas 58
References 63
3 Technological Platform of Tcm Chemomics 66
3.1 Acquisition Methods and Techniques for TCM Chemomics 66
3.2 Characterization Techniques of Chemome-TCM Fingerprinting 73
3.3 Information Processing for the Study of TCM Chemomics 107
3.4 Development of an Intelligent Quality Control System in the Process of Chinese Medicine Production 119
References 127
4 Pharmacokinetic Investigation on Tcm Formulas Based on Global Systems Biology 131
4.1 Pharmaco…