The rapid rise of AI and the growing complexity of financial markets have transformed quantitative trading into a data-driven, process-oriented discipline. This third edition provides a comprehensive blueprint for designing, validating, and deploying systematic trading strategies powered by modern machine learning. It introduces the 7 stage ML4T Workflow, a professional framework that unites data engineering, model development, validation, and live deployment into one cohesive process. It demonstrates how to turn raw market, fundamental, and alternative data into predictive signals and robust, production-ready trading systems. You'll learn to build advanced pipelines for feature engineering, model evaluation, and portfolio optimization using libraries such as Polars, LightGBM, PyTorch, and Optuna. Practical notebooks illustrate every stage of the workflow, from factor testing and backtesting with zipline reloaded to live deployment with MLOps tools such as MLflow, Feast, and Prometheus. Additional coverage of synthetic data generation, Graph Neural Networks, and Reinforcement Learning extends the toolkit for building resilient, adaptive strategies that thrive in dynamic markets. By the end of this book, you'll be proficient to build your own industrial-grade "alpha factory".