Until recently, diagnosis and treatment of Parkinson s Disease was focused on the early phase of the illness. In the last few years, complications such as dyskinesia, autonomic dysregulation and psychiatric disturbances have drawn more attention, thus inspiring several novel diagnostic and therapeutic approaches. This textbook depicts the symptoms of advanced Parkinson s Disease and state-of-the-art treatment options, including special therapeutic strategies such as the apomorphine pump, the duodopa pump, deep brain stimulation or gene therapy. The competent and experienced authors impart all information of practical relevance in this field.